Definition: The Japanese encephalitis virus (JEV) vaccine inactivated and adsorbed refers to a type of vaccine designed for the prevention or treatment of a specific infectious disease caused by JEV. Inactivated vaccines are vaccines that contain a weakened version of the virus, which does not cause the disease itself but can protect against its symptoms. Adsorption is the process where an immunogenic substance (such as a protein in the vaccine) binds to the surface of the host cell and induces an immune response, typically leading to temporary immunity. JEV is a highly contagious respiratory pathogen that affects humans. It is transmitted through close contact with infected droplets from coughs, sneezes, or nose blisters. The virus is especially dangerous in immunocompromised individuals like those with HIV/AIDS, or those who are at high risk of getting infections due to other conditions. Inactivation and adsorption work together to prevent the disease and protect against symptoms. For example, a vaccine that contains a weakened version of JEV but adsorbs it on the surface of immune cells in the body can help prevent infection by blocking its entry into the bloodstream. The adsorbed version of the virus may also be used if there is a failure to induce an immune response. The adhesion of the immunogenic particles, which are proteins or other components in the vaccine, allows them to bind to specific cell receptors on the surface of immune cells. This process can lead to temporary protection against JEV infection and subsequent disease symptoms. In summary, Japanese encephalitis virus vaccines inactivated and adsorbed aim to prevent the spread of the virus, protect healthy individuals from infection, and potentially treat or control some cases ofJEV infection if they are administered properly.
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